Display Options: Structure:  

Goto PDB code:

3D presentation of molecule is powered by 3Dmol, which supports all modern browsers and mobile devices via WebGL.

Hold mouse button: left to rotate,middle to shift,right to zoom

Related entries of code: 2i1m
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
2i0vRCSB PDB    PDBbind335aa, >2I0V:A|PDBID|CHAIN|... at 91%
2i0yRCSB PDB    PDBbind335aa, >2I0Y:A|PDBID|CHAIN|... at 91%
3beaRCSB PDB    PDBbind333aa, >3BEA:A|PDBID|CHAIN|... at 91%
3dpkRCSB PDB    PDBbind335aa, >3DPK:A|PDBID|CHAIN|... at 91%
3krjRCSB PDB    PDBbind335aa, >3KRJ:A|PDBID|CHAIN|... at 91%
3krlRCSB PDB    PDBbind335aa, >3KRL:A|PDBID|CHAIN|... at 91%
3lcdRCSB PDB    PDBbind329aa, >3LCD:A|PDBID|CHAIN|... at 95%
3lcoRCSB PDB    PDBbind324aa, >3LCO:A|PDBID|CHAIN|... at 98%
4hw7RCSB PDB    PDBbind343aa, >4HW7:A|PDBID|CHAIN|... *
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
2i0yRCSB PDB    PDBbind5CN

Entry Information
PDB ID2i1m
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NamecFMS tyrosine kinase (tie2 KID)
Ligand Name5CN
EC.Number E.C.
Resolution 1.8(Å)
Affinity (Kd/Ki/IC50)IC50=24nM
Release Year2006
Protein/NA SequenceCheck fasta file
Primary ReferenceJ. Biol. Chem. 2007, 282, 4094-4101.
Ligand Properties
Formula C19H21N3O3
Molecular Weight 339.388
Exact Mass 339.158
No. of atoms 46
No. of bonds 48
Polar Surface Area 89.5
LOGP Value 2.73      (Computed with XLOGP3)
3.27      (Computed with Open Babel)
Drug likenessNo. of Hydrogen Bond Donors: 2
No. of Hydrogen Bond Acceptors: 3
No. of Rotatable Bonds: 6
No. of Nitrogen and Oxygen Atoms: 6
No. of Rings: 3
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P07333  
Entrez Gene IDNCBI Entrez Gene ID: 1436  
ASDInformation of known allosteric effects of PDB entries

This site has been visited times since Nov 2007.

Address: 826 Zhangheng Road, Shanghai 201203, People's Republic of China      ICP NO: Shanghai-05005485-2
Group Leader: wangrx@fudan.edu.cn      Tel: +86-21-54925128      Webmaster: liuhai@mail.sioc.ac.cn
Copyright ©2007-2020    Department of Medicinal Chemistry, School of Pharmacy, Fudan University, P.R. China